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Commit fd633e41 authored by Bakker, Sibbe's avatar Bakker, Sibbe :speech_balloon:
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Add more introduction.

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......@@ -17,12 +17,29 @@ title-slide-attributes:
data-background-size: cover
data-background-image: inclusions/blurred-asper.jpg
data-background-opacity: "0.5"
data-background-color: "black"
date: "2024-01-15"
bibliography: "BibDataBase.bib"
---
# Relivance of fungi {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
::: incremental
* Fungi are a diverse taxa.
* A lot good things
- Fermentation.
- Plant health.
- Nutrient cycling.
* A lot of chaos too
- Food insecurity.
- Toxicity of food.
- Diseases in animals.
:::
## The WHO priority pathogens {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
![The priority fungal pathogens identified by
the WHO [@worldhealthorganizationwhoWHOFungalPriority2022]](
inclusions/who-priorities.png)
......@@ -68,7 +85,7 @@ work with it -->
phylogeography.
## Nextstrain {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
## Phylogeography using nextstrain {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
Using `nextstrain` for fungal pathogens [@hadfieldNextstrainRealtimeTracking2018]. An example:
......@@ -81,28 +98,62 @@ Using `nextstrain` for fungal pathogens [@hadfieldNextstrainRealtimeTracking2018
> This has not yet been done because $\dots$
* Whole genome sequences of fungi are upcoming: [@fanComparativeGenomeSequence2020; @lofgrenPangenomeAspergillusFumigatus2022; @rhodesPopulationGenomicsConfirms2022]
::: incremental
* Whole genome sequences (WGS) of fungi are [upcoming]{.alert}: [@fanComparativeGenomeSequence2020; @lofgrenPangenomeAspergillusFumigatus2022; @rhodesPopulationGenomicsConfirms2022]
* Existing solutions [don't consider]{.alert} WGS data.
* Standardisation is not a focus in the _A. fumigatus_ domain.
* Standardisation is [not a focus]{.alert} in the _A. fumigatus_ domain.
:::
# Method {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
1. Harmonise _existent_ metadata.
::: incremental
1. Harmonise [existent]{.alert} metadata.
2. Develop a system for harmonising [new]{.alert} metadata.
3. Analyse [phylogeography]{.alert} of *A. fumigatus*.
2. Develop a system for harmonising _new_ metadata.
4. Generalise the workflow to [other fungi]{.alert}.
3. Analyse phylogeography of *A. fumigatus*.
:::
::: notes
Why me? I have the domain knowledge and network, and the technical ability
and will power to pull it off.
:::
4. Generalise the workflow to other fungi.
# Outlook {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
* This would represent an innovation in the fungal database field.
::: incremental
* A new method of data collection.
* Existing solutions, like [globalfungi](https://globalfungi.com/) only focus
on the _ITS_ sequence.
* The solution could be generalised to plant epidemiology also.
* The solution [could be generalised]{.alert} to plant epidemiology also.
:::
# References {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
# References {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
\ No newline at end of file
## More information {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
* [`sibbe.bakker@wur.nl`](mailto:sibbe.bakker@wur.nl)
* Read my [pre-proposal](https://bookdown.org/sibbe_l_bakker/pre-proposal/)
* I thank Eveline Snelders and Christopher Wandabwa for reviewing my work.
## Cited works {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
::: {#refs}
:::
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