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Grant proposal for knowledge graphs and transposable elements.
presentations
assignment-2
Commits
9b755b59
Commit
9b755b59
authored
1 year ago
by
Bakker, Sibbe
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title: "FAIR data for a better understanding of fungal epidemiology"
author:
- name: "[Sibbe Bakker](https://orcid.org/0009-0001-0696-1684)"
affiliation:
Bioinforma
tics
affiliation:
Gene
tics
- name: "Anna Fensel"
affiliation: AI & Data science
format:
revealjs:
self-contained: true
csl: diabetologia.csl
csl: diabetologia.csl
theme: aspar.scss
standalone: true
embed-resources: true
navigation-mode: vertical
controls-layout: bottom-right
title-slide-attributes:
data-background-size: cover
data-background-image: inclusions/blurred-asper.jpg
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@@ -18,46 +21,63 @@ date: "2024-01-15"
bibliography: "BibDataBase.bib"
---
#
# Relivance of fung
al pathogens
# Relivance of fung
i {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
![The priority fungal pathogens identified by
the WHO [@worldhealthorganizationwhoWHOFungalPriority2022]](
inclusions/who-priorities.png)
## A closer look at _A. fumigatus_
::: notes
Highlight what these fungi are, how important are they and where?
:::
---
## A closer look at _A. fumigatus_ {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
<!-- Why are we looking here? Because the genetics department does a lot of
work with it -->
* Why? Because the WUR has expertise on _A. fumigatus_.
* It is important for Dutch public health. <br> _Due to the large tulip sector here._
::: columns
## The knowledge gap
::: {.column width="60%"}
::: {.r-stack}
* Why? Because the WUR has [expertise]{.alert} on _A. fumigatus_.
* It is [imporant]{.alert} for Dutch public health. <br> _Due to the large tulip sector here._
:::
{.fragment fragment-index=1 .fade-out}
:::
> Being able to track the evolution of fungal pathogens.
::: {.column width="40%"}
![Conidia of _A. fumigatus_ [@OneHealthFungal2019]](inclusions/aspergillus-fromNBK54998.jpg)
:::
:::
{.fragment fragment-index=2 .fade-in-then-out}
:::
* This is called phylogeography.
:::
# The knowledge gap {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
## What we need to do {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
> Being able to track the evolution of fungal pathogens.
## How do we do it? {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
phylogeography.
## Nextstrain {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
::: {.fragment fragment-index=3 .fade-in-then-out}
Using `nextstrain` for fungal pathogens [@hadfieldNextstrainRealtimeTracking2018]. An example:
.
](inclusions/west-nile.png)
:::
::: {.fragment fragment-index=4 .fade-in-then-out
}
## Bridging the gap {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"
}
> This has not yet been done because $\dots$
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@@ -65,11 +85,8 @@ Using `nextstrain` for fungal pathogens [@hadfieldNextstrainRealtimeTracking2018
* Standardisation is not a focus in the _A. fumigatus_ domain.
:::
:::
#
# Method
# Method
{background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
1. Harmonise _existent_ metadata.
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@@ -79,7 +96,7 @@ Using `nextstrain` for fungal pathogens [@hadfieldNextstrainRealtimeTracking2018
4. Generalise the workflow to other fungi.
#
# Outlook
# Outlook
{background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
* This would represent an innovation in the fungal database field.
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@@ -88,4 +105,4 @@ on the _ITS_ sequence.
* The solution could be generalised to plant epidemiology also.
## References
\ No newline at end of file
# References {background-color="black" background-image="inclusions/blurred-asper.jpg" background-size="cover" background-opacity="0.5"}
\ No newline at end of file
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