BiG-SCAPE
BiG-SCAPE (Biosynthetic Gene Similarity Clustering and Prospecting Engine) is a Python script that calculates a distance matrix between groups of genes. In particular, BiG-SCAPE has been built with the aim of analyzing Biosynthetic Gene Clusters, which encode the pathways for Secondary Metabolites.
BiG-SCAPE works by predicting and comparing conserved domains found in the proteins encoded in the gene clusters.
This comparison allows to form a distance matrix that can be used to group similar BGCs automatically.
Learn more about BiG-SCAPE in the wiki.
