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Jorge Navarro Muñoz's avatar
CHANGES IN DEFAULT PARAMETERS
Jorge Navarro Muñoz authored 
- hybrids mode is now default. Use --hybrids-off to turn it off
- cutoffs now has a single default value: 0.3
- clans clustering is now activated by default. Use --clans-off to turn
it off
- clan_cutoff is now 0.3 0.7 (i.e. will use GCFs defined at 0.3 and will
form GCC using average distance between GCFs of 0.7 or less)
15c0ce69
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Jorge Navarro Muñoz's avatar 15c0ce69
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Name Last commit Last update
Annotated_MIBiG_reference
html_template
ArrowerSVG.py
BiG-SCAPE CORASON Workflow.png
Dockerfile.bin
LICENSE
README.md
anchor_domains.txt
bigscape.py
domains_color_file.tsv
functions.py
README.md

BiG-SCAPE

BiG-SCAPE (Biosynthetic Gene Similarity Clustering and Prospecting Engine) is a Python script that calculates a distance matrix between groups of genes. In particular, BiG-SCAPE has been built with the aim of analyzing Biosynthetic Gene Clusters, which encode the pathways for Secondary Metabolites.

BiG-SCAPE works by predicting and comparing conserved domains found in the proteins encoded in the gene clusters.

This comparison allows to form a distance matrix that can be used to group similar BGCs automatically.

Learn more about BiG-SCAPE in the wiki.

![](BiG-SCAPE CORASON Workflow.png)